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KMID : 0984920080100010061
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Journal of Skin Barrier Research
2008 Volume.10 No. 1 p.61 ~ p.72
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Prospect of development of transdermal patch for Alzheimer’s disease
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Choi Joon-Ho
Kim Dae-Duk
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Abstract
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The purpose of this review is to summarize the background about Alzheimer’s disease and the investigation for design of transdermal delivery of acetylcholinesterase inhibitor(AChEI). The first and the only skin patch for the symptomatic treatment of Alzheimer’s dementia selects rivastigmine among these AChEIs as an active ingredient. In terms of a transdermal delivery, rivastigmine has good pharmacodynamic features with the brain-region selectivity and a long
duration of action and good physicochemical properties with oral bioavailability of 35%, short pharmacokinetic half life, low daily dose, small molecular weights and high lipid solubility. And it obviously is the merit above all others that may offer convenience to caregivers and patients. Finally, to control the transdermal delivery of rivastigmine, feasibility of applications of pressuresensitive adhesive(PSA) and chemical permeaion enhancer(CPE) was discussed.
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KEYWORD
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Alzheimer’s disease, Transdermal delivery, acetylcholinesterase inhibitor, adhesive, enhancer
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